Sébastien Pouderoux was trained at the École du Théâtre National de Strasbourg between 2004 and 2007, where he encountered various directors including Christophe Rauck with whom he worked on Innocence by Dea Loher and Alain Françon who cast him in Maxim Gorky’s Children of the Sun (Les Enfants du soleil). They reunited again several years later for Chekhov’s Cherry Orchard (La Cerisaie). Stéphane Braunschweig directed in Molière’s Le Tartuffe, while Daniel Jeanneteau and Marie-Christine Soma directed him in Eugène Labiche’s L’Affaire de la rue Lourcine. Christophe Honoré cast him in his adaptation of Victor Hugo’s Angelo, Tyrant of Padua (Angelo, tyran de Padoue), staged at the Festival d’Avignon in 2009. He also gave Sébastien Pouderoux a part in his movie Homme au bain. Two years later, they reunited in Avignon to create Nouveau roman, a play where Pouderoux plays Claude Simon. In 2011, together with Marie Rémond and Clément Bresson, two students from his graduating class, he co-wrote and played in André, based on the biography of André Agassi. The threesome returned with another show entitled Vers Wanda.

Sébastien Pouderoux has been a pensionnaire of the Comédie-Française since 2012, where he made his debut playing Achilles in Shakespeare’s Troilus and Cressida directed by Jean-Yves Ruf. He has worked with Clément Hervieu-Léger on Molière’s Le Misanthrope; Lilo Baur on Federico García Lorca’s The House of Bernarda Alba (La Maison de Bernarda Alba) and Sergi Belbel’s Après la pluie; Muriel Mayette-Holtz on Shakespeare’s A Midsummer Night’s Dream and Racine’s Andromache (Andromaque); Jacques Vincey on Molière’s Amphitryon; Denis Podalydès on Edmond Rostand’s Cyrano de Bergerac and Lucrezia Borgia by Victor Hugo; Denis Marleau on Innocence by Dea Loher; and Dan Jemmett on Shakespeare’s Hamlet. In 2015, he interpreted Bob Dylan in Greil Marcus’s Like a Rolling Stone (Comme une pierre qui…), which he co-directed with Marie Rémond. Ivo Van Hove cast him as Herbert Thallman in The Damned, an adaptation of Visconti’s film.

Outside of the Comédie-Française, Sébastien Pouderoux played in Thomas Ostermeier’s adaptation of Chekhov’s Seagull (La Mouette) in 2016. His filmography includes The French Minister (Quai d’Orsay) by Bertrand Tavernier, All Three of Us (Nous trois ou rien) by Kheiron, Just a Sigh (Le Temps de l’aventure) and The Queen of Clubs (La Dame de trèfle) by Jérôme Bonnell. He was part of the ensemble cast for Olivier Nakache and Eric Toledano’s film C'est la Vie (Le Sens de la fête). Guillaume Gallienne directed him in the television adaptation of Oblomov by Ivan Goncharov, and later in his feature film Maryline.

During the 2018/2019 season, Sébastien Pouderoux will be playing in Shakespeare’s The Twelfth Night or What You Will by Thomas Ostermeier, Leila Slimani’s Chanson douce by Pauline Bayle, and Les Serge (Gainsbourg Point Barre) written and directed with Stéphane Varupenne. He will be also playing in the reruns of Racine’s Britannicus by Stéphane Braunschweig and Visconti’s The Damned by Ivo van Hove.